Gastrin-1, rat - 1 mg
- Cat.Number : AS-20752
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Like human Gastrin-1 “Little Gastrin,” rat Gastrin-1 “Little Gastrin” contains 17 amino acids, but differs from human Gastrin by 3 amino acids at the C-terminus. Secretion of Gastrin is induced by food intake and causes the release of gastric acid. Synthesized by the G cells in the gastric mucosa, it is one of the major bioactive forms of Gastrin (the other bioactive form is Gastrin-34). Both Gastrin-17 and Gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of Gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor.
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Citations
Mesenchymal Cells Appearing in Pancreatic Tissue Culture Are Bone Marrow-Derived Stem Cells With the Capacity to Improve Transplanted Islet Function.
Stemm Cells . 2010 Jan 01 ; 28(1) 140 | DOI : 10.1002/stem.259
- V. Sordi
References
Digestive Function of the Stomach
Digestive Dis . 2014 Apr 10 ; 32(3) 186 | DOI : 10.1159/000357848.
- A. O’Connor
- et al
Gastrin: Old Hormone, New Functions
Pflügers Archiv . 2005 Jan 01 ; 449(4) 344 | DOI : 10.1007/s00424-004-1347-5
- G. Dockray
- et al
New Consensus Features for Tyrosine O-sulfation Determined by Mutational Analysis
JBC . 1997 Aug 29 ; 272(35) 21700 | DOI : 10.1074/jbc.272.35.21700.
- JR. Bundgaard
- et al
Ghrelin and Gastric Acid Secretion
World J Gastroenterol . 2008 Nov 07 ; 14(41) 6334 | DOI : 10.3748/wjg.14.6334.
- K. Yakabi
- et al
Hypergastrinemia--diagnosis and treatment.
Wien Klin Wochenschr . 2006 Dec 31 ; 119(19-20) 561 | DOI : 10.1007/s00508-007-0897-x.
- B. Niederle
Unique Amino Terminal Structure of Rat Little Gastrin
Peptides . 1981 Oct 26 ; 2(4) 453 | DOI : 10.1016/s0196-9781(81)80104-0
- JR. Reeve
- et al
Rat gastrin's amino acid sequence determined from the nucleotide sequence of the mRNA
Peptides . 1982 Jul 08 ; 3(4) 693 | DOI : 10.1016/0196-9781(82)90172-3
- MH. Schaffer
- et al
Rat gastrin's amino acid sequence determined from the nucleotide sequence of the mRNA
Peptides . 1982 Jul 31 ; 3(4) 693 | DOI : https://doi.org/10.1016/0196-9781(82)90172-3
- MH. Schaffer
- et al