IMG-EN-AS-22460-01.jpg
Peptides

Glucagon-Like Peptide 1, GLP-1 (1-36) amide, human, mouse, rat, bovine, guinea pig - 0.5 mg

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  • Cat.Number : AS-22460
  • Availability :
    In stock

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In response to Glucose ingestion, proglucagon in the intestinal L cells is cleaved into GLP-1 (1-36). Prior to secretion into the circulation, GLP-1 (1-36) is further processed into amidated GLP-1 (7-36) and small amounts of glycine-extended GLP-1 (7-37). Both GLP-1 (7-36) and GLP-1 (7-37), causes glucose dependent release of insulin by pancreatic beta-cells. They also play a role in gastric motility (gastric emptying), on the suppression of plasma glucagon levels (glucose production) and possibly on the promotion of satiety and stimulation of glucose disposal in peripheral tissues independent of the actions of insulin. GLP-1 peptides such as GLP-1 (1-36) have been used to investigate restoration of pancreatic beta cell function. GLP-1 is also produced in the central nervous system.

Specifications

Chemistry
Sequence one letter code
  • HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Sequence three letter code
  • H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
CAS registry number
  • 99658-04-5
Molecular Formula
  • C184H273N51O57
Molecular Mass/ Weight
  • 4111.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

PNAS . 1987 May 01 ; 84(10) 3434 | DOI : 10.1073/pnas.84.10.3434

  • D. Drucker
  • et al

The Glucagon-Like Peptides

Endo Rev . 1999 Dec 01 ; 20(6) 876 | DOI : https://doi.org/10.1210/edrv.20.6.0385

  • T. Kieffer
  • et al

Circulation and degradation of GIP and GLP-1

Hormone Metab Res . 2004 Nov 12 ; 36(11-12) 761 | DOI : 10.1055/s-2004-826160.

  • CF. Deacon
  • et al

GLP-1

Pancreadepedia . 2014 May 12 ; | DOI : 10.3998/panc.2014.7

  • JA. Williams
  • et al