Glucagon-Like Peptide 1, GLP-1 (7-36), amide, human [FAM-Trp31] - 0.5 mg
- Cat.Number : AS-64488
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This GLP-1 (7-36) amide peptide is fluorescently labeled at Tryptophan residue 25 with Fluorescein. GLP-1 (7-36) amide is an incretin hormone that causes glucose dependent release of insulin by pancreatic beta cells. It is the cleavage product of GLP-1 (1-36) amide peptide. Both GLP-1 (7-36) and GLP-1 (7-37), also play roles in gastric motility (gastric emptying), on the suppression of plasma glucagon levels (glucose production) and possibly on the promotion of satiety and stimulation of glucose disposal in peripheral tissues independent of the actions of insulin. GLP-1 (7-36) has a short half life of less than 2 minutes, and like GIP, is rapidly degraded by the enzyme dipeptidyl peptidase IV (DPP-4), which is widely expressed in a number of sites, including the endothelial cells of small gut arterioles. DPP-4 degrades GLP-1 (7-36) into the non insulinotropic GLP-1 (9-36) (some studies suggest it may have weak insulinotropic activity). As a result, the majority of GLP-1 (and GIP) is inactivated as an insulinotrope before reaching the systemic circulation.
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References
Fluorescein-Trp25-Exendin-4, a Biologically Active Fluorescent Probe for the Human GLP-1 Receptor
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The Glucagon-Like Peptides
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Circulation and degradation of GIP and GLP-1
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- et al
GLP-1
Pancreadepedia . 2014 May 12 ; | DOI : 10.3998/panc.2014.7
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- et al
GLP‐1 (9–36) Amide, Cleavage Product of GLP‐1 (7–36) Amide, Is a Glucoregulatory Peptide
Obesity . 2012 Sep 06 ; 16(7) 1501 | DOI : https://doi.org/10.1038/oby.2008.229
- D. Elahi
- et al
Glucagon-Like Peptide (GLP)-1(9-36)Amide-Mediated Cytoprotection Is Blocked by Exendin(9-39) Yet Does Not Require the Known GLP-1 Receptor
Endocrinol . 2012 Sep 06 ; 151(4) 1520 | DOI : https://doi.org/10.1210/en.2009-1197
- K. Ban
- et al