IMG-EN-AS-20761-01.jpg
Peptides

Glucagon-Like Peptide 1, GLP-1 (7-37) human, mouse, rat, bovine, guinea pig

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  • Cat.Number : AS-20761
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GLP-1 (7-37) is an incretin hormone that causes glucose dependent release of insulin by pancreatic beta cells. It is the cleavage product of proglucagon. Both GLP-1 (7-36) and GLP-1 (7-37) play roles in gastric motility (gastric emptying), on the suppression of plasma glucagon levels (glucose production) and possibly on the promotion of satiety and stimulation of glucose disposal in peripheral tissues independent of the actions of insulin. Although GLP-1 (7-37) is bioactive, it is available in lesser amounts than GLP-1 (7-36) and is not amidated.

Specifications

Chemistry
Sequence one letter code
  • HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Sequence three letter code
  • H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH
CAS registry number
  • 106612-94-6
Molecular Formula
  • C151H228N40O47
Molecular Mass/ Weight
  • 3355.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, sheep, rat, mouse, hamster, bovine

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References

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

PNAS . 1987 May 01 ; 84(10) 3434 | DOI : 10.1073/pnas.84.10.3434

  • D. Drucker
  • et al

Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors

Receptors Channels . 2002 Aug 01 ; 8(3-4) 179 | DOI : PMID: 12529935

  • P. Brubaker
  • D. Drucker

Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes

Am J Physiol Cell Physiol . 2001 Nov 01 ; 281 C1495 | DOI : https://doi.org/10.1152/ajpcell.2001.281.5.C1495

  • J. Leonova
  • et al

On the potential role of glutamate transport in mental fatigue

J Neuroinflamm . 2004 Nov 04 ; 1 22 | DOI : doi: 10.1186/1742-2094-1-22

  • L. Rönnbäck
  • E. Hansson

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

Neuron . 1996 Mar 01 ; 16 675 | DOI : 10.1016/s0896-6273(00)80086-0

  • JD. Rothstein
  • et al