IMG-EN-AS-62753-01.jpg
Peptides

Histone H3 (1-20) - 1 mg

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  • Cat.Number : AS-62753
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This is amino acids 1 to 20 fragment of the histone H3. Comparison the acetylation efficiency of different substrates showed that this peptide corresponding to the N-terminal of H3 histone has nearly identical acetylation efficiency as the H4 peptides. Acetylation of histones is generally associated with active transcription, constitutes a post-translational mark recognized by specific chromatin factors, and has been shown in vitro to prevent salt-induced folding of nucleosome arrays. Multisubunit histone acetyltransferase (HAT) complexes recognize and perform efficient acetylation on nucleosome substrates.

Specifications

Chemistry
Sequence one letter code
  • ARTKQTARKSTGGKAPRKQL
Sequence three letter code
  • H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-OH
Molecular Formula
  • C91H167N35O27
Molecular Mass/ Weight
  • 2183.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Nucleosome Recognition by the Piccolo NuA4 Histone Acetyltransferase Complex

Biochem . 2007 Feb 03 ; 46(8) 2091 | DOI : https://doi.org/10.1021/bi602366n

  • C. Berndsen
  • et al