Histone H3 (5-23) - 1 mg
- Cat.Number : AS-65135
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This peptide represents amino acid residues 5-23 of histone H3 and can be used as a substrate for histone acetyl-transferase (HAT) assays.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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References
Mutagenesis of tGCN5 core region reveals two critical surface residues F90 and R140
Biochem Biophys Res Commun . 2010 Sep 24 ; 400(3) 363 | DOI : https://doi.org/10.1016/j.bbrc.2010.08.069
- K. Mehta
- et al
The Human Monocytic Leukemia Zinc Finger Histone Acetyltransferase Domain Contains DNA-binding Activity Implicated in Chromatin Targeting
J Biol Chem . 2007 Dec 01 ; 282(50) 36603 | DOI : https://doi.org/10.1074/jbc.M705812200
- M. Holbert
- et al