Peptides

Histone H3 (5-23) - 1 mg

$113.00
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  • Cat.Number : AS-65135
  • Availability :
    In stock

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This peptide represents amino acid residues 5-23 of histone H3 and can be used as a substrate for histone acetyl-transferase (HAT) assays.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • QTARKSTGGKAPRKQLASK
Sequence three letter code
  • H-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Ser-Lys-OH
Molecular Formula
  • C84H153N31O26
Molecular Mass/ Weight
  • 2013.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Mutagenesis of tGCN5 core region reveals two critical surface residues F90 and R140

Biochem Biophys Res Commun . 2010 Sep 24 ; 400(3) 363 | DOI : https://doi.org/10.1016/j.bbrc.2010.08.069

  • K. Mehta
  • et al

The Human Monocytic Leukemia Zinc Finger Histone Acetyltransferase Domain Contains DNA-binding Activity Implicated in Chromatin Targeting

J Biol Chem . 2007 Dec 01 ; 282(50) 36603 | DOI : https://doi.org/10.1074/jbc.M705812200

  • M. Holbert
  • et al