IMG-EN-AS-65425-01.jpg
Peptides

Histone H3 (69-89)-NH2 - 1 mg

$226.00
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  • Cat.Number : AS-65425
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H3K69 methylation is generally associated with transcriptional activation, with methylation catalyzed by DOT/DOT1L enzyme in the context of a nucleosome. Aberrant methylation of H3K79 has been implicated in leukemias. Histone H3 (69-89) peptides are used for assessing the specificity of anti-H3K79me antibodies.

Specifications

Chemistry
Sequence one letter code
  • RLVREIAQDFKTDLRFQSSAV-NH2
Sequence three letter code
  • H-Arg-Leu-Val-Arg-Glu-Ile-Ala-Gln-Asp-Phe-Lys-Thr-Asp-Leu-Arg-Phe-Gln-Ser-Ser-Ala-Val-NH2
Molecular Formula
  • C109H180N34O32
Molecular Mass/ Weight
  • 2479
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Histone methylation in transcriptional control

Curr Opin Genet Dev . 2002 Apr 01 ; 12(2) 198 | DOI : https://doi.org/10.1016/S0959-437X(02)00287-3

  • Tony Kouzarides

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

Genes Dev . 2002 Jun 15 ; 16(12) 1518 | DOI : 10.1101/gad.1001502

  • HH. Ng
  • et al