Histone H3 (69-89)-NH2 - 1 mg
- Cat.Number : AS-65425
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H3K69 methylation is generally associated with transcriptional activation, with methylation catalyzed by DOT/DOT1L enzyme in the context of a nucleosome. Aberrant methylation of H3K79 has been implicated in leukemias. Histone H3 (69-89) peptides are used for assessing the specificity of anti-H3K79me antibodies.
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References
Histone methylation in transcriptional control
Curr Opin Genet Dev . 2002 Apr 01 ; 12(2) 198 | DOI : https://doi.org/10.1016/S0959-437X(02)00287-3
- Tony Kouzarides
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association
Genes Dev . 2002 Jun 15 ; 16(12) 1518 | DOI : 10.1101/gad.1001502
- HH. Ng
- et al