Histone H4 (1-7), N-Terminal - 1 mg
- Cat.Number : AS-62754
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This is amino acids 1 to 7 fragment of the histone H4. Alterations in chromatin structure, such as nucleosome sliding, removal of nucleosomes, and disruption of DNA–histone or histone–histone contacts through post-translational modification of the histones, have been linked to transcriptional regulation, DNA damage repair, and replication, among other cellular processes. Modification of histones occurs primarily in the N-terminal residues or tail region. These modifications include phosphorylation, ubiquitinylation, methylation, sumolyation, and acetylation. Lys5 may serve as the acetylation site for this peptide.
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References
Nucleosome Recognition by the Piccolo NuA4 Histone Acetyltransferase Complex
Biochem . 2007 Feb 03 ; 46(8) 2091 | DOI : https://doi.org/10.1021/bi602366n
- C. Berndsen
- et al