Peptides

Histone H4 (1-7), N-Terminal - 1 mg

  • Cat.Number : AS-62754
  • Availability :
    In stock

Quantity

This is amino acids 1 to 7 fragment of the histone H4. Alterations in chromatin structure, such as nucleosome sliding, removal of nucleosomes, and disruption of DNA–histone or histone–histone contacts through post-translational modification of the histones, have been linked to transcriptional regulation, DNA damage repair, and replication, among other cellular processes. Modification of histones occurs primarily in the N-terminal residues or tail region. These modifications include phosphorylation, ubiquitinylation, methylation, sumolyation, and acetylation. Lys5 may serve as the acetylation site for this peptide.

Specifications

Chemistry
Sequence one letter code
  • SGRGKGG
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-OH
Molecular Formula
  • C23H43N11O9
Molecular Mass/ Weight
  • 617.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Nucleosome Recognition by the Piccolo NuA4 Histone Acetyltransferase Complex

Biochem . 2007 Feb 03 ; 46(8) 2091 | DOI : https://doi.org/10.1021/bi602366n

  • C. Berndsen
  • et al