Human PD-L1 inhibitor IV - 1 mg
- Cat.Number : AS-65584
- Manufacturer Ref. :
-
Availability :
In stock
Alternative choices
Programed cell death 1 (PD-1) receptor and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells were identified to overexpress PD-L1 so as to escape from the PD-1/PD-L1 immunosurveillance mechanism. This peptide, hPDL-1 inhibitor IV binds to human PD-1 and inhibits PD-1/PD-L1 binding. It has anchor residues (underlined), GNWDYNSQRAQLYNQ that show a great impact on the binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway became popular approach to cancer treatment.
Specifications
Chemistry | |
Sequence one letter code |
|
---|---|
Sequence three letter code |
|
Molecular Formula |
|
Molecular Mass/ Weight |
|
Modification | |
Conjugation |
|
Quantity & Purity | |
Purity |
|
Storage & stability | |
Form |
|
Storage Conditions |
|
Activity | |
Biomarker Target | |
Research Area | |
Sub-category Research Area | |
Usage |
|
Source | |
Source / Species |
|
Downloads
You may also be interested in the following product(s)
![IMG-EN-AS-72241-01.jpg](/assets/cache/d5961f67-20b3-40f1-beb3-1d45ea170231/500x500/as-72241-img-en-as-72241-01.jpg)
SensoLyte® Rh110 Matriptase Activity Assay Kit Fluorimetric - 1 kit
![IMG-EN-AS-60877-01.jpg](/assets/cache/876c5905-fcdb-4ea5-a25f-2ff49d07564c/500x500/as-60877-img-en-as-60877-01.jpg)
References
A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet.
Clin Transl Med . 2017 Dec 01 ; 6(1) 3 | DOI : 10.1186/s40169-016-0130-5
- G. D'Errico
- et al
Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor
Oncotarget . 2016 Oct 04 ; 7(40) 64967 | DOI : 10.18632/oncotarget.11274
- Q. Li
- et al
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation
Front Immunol . 2016 Dec 12 ; 7 550 | DOI : 10.3389/fimmu.2016.00550
- K. Bardhan
- et al