Insulin B (15-23) - 1 mg
- Cat.Number : AS-63773
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This is amino acids 15 to 23 fragment of the insulin b chain recognized by islet-associated T cells. This peptide is also known as INS. It was used in diabetes studies to assay the IFN-b and IL-17 production by diabetogenic CD4 or CD8 T cells. This peptide stains the INS-reactive CTL clone, but doesn’t stain the splenic CD8+ T cells from NOD or 8.3-TCR-transgenic NOD mice.
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References
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
J Clin Invest. . 2007 Dec 03 ; 117 3857 | DOI : 10.1172/JCI32405
- C. Hu
- et al
Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand
J Immunol . 2003 Dec 15 ; 171 3857 | DOI : https://doi.org/10.4049/jimmunol.171.12.6954
- N. Martin-Orozco
- et al