Peptides

[Lys(Ac)12]-Histone H4 (1-20) - 1 mg

$195.00
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  • Cat.Number : AS-63685
  • Availability :
    In stock

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This peptide is Histone 4 acetylated at lysine 12. Based on genome-wide localization studies, this peptide has been found to occupy promoter region at the transcription start sites, especially being associated with particular promoters that may drive high levels of mRNA transcripts stored in mature spermatozoa. Such observations have led to assumptions that H4K12Ac may be one of the epigenetic marks for developmentally important genes.

Specifications

Chemistry
Sequence one letter code
  • SGRGKGGKGLG-K(Ac)-GGAKRHRK
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys(Ac)-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-OH
Molecular Mass/ Weight
  • 2034.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development

Epigenetics . 2012 Aug 16 ; 7(9) 1057 | DOI : https://doi.org/10.4161/epi.21556

  • AS. Paradowska

Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases

Biochem. . 2004 Jul 10 ; 43(30) 9877 | DOI : https://doi.org/10.1021/bi049592e

  • MT. Borra
  • et al