Peptides

[Lys(Ac)14]-Histone H3 (9-19) - 1 mg

  • Cat.Number : AS-63681
  • Availability :
    In stock

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Quantity

This is a H3 peptide acetylated at the lysine residue at the 14th position. This peptide has been shown to act as part of the active promoter state and the extent of its acetylation could be driven by cis regulatory elements such as CpG contents at promoters. It's expression has been shown to be decreased as malignancy of ovarian epithelial tumors increased, suggesting that this peptide could act as a prognostic marker although it does not show significant relation with the occurence or development of ovarian tumors.

Specifications

Chemistry
Sequence one letter code
  • KSTGG-K(Ac)-APRKQ
Sequence three letter code
  • H-Lys-Ser-Thr-Gly-Gly-Lys(Ac)-Ala-Pro-Arg-Lys-Gln-OH
Molecular Formula
  • C50H90N18O16
Molecular Mass/ Weight
  • 1199.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases

Biochem. . 2004 Jul 10 ; 43(30) 9877 | DOI : https://doi.org/10.1021/bi049592e

  • MT. Borra
  • et al