Peptides

[Lys(Ac)16]-Histone H4 (1-20) - 1 mg

$195.00
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  • Cat.Number : AS-63687
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    In stock

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This Histone 4 peptide is acetylated at lysine 16. Lysine 16 of H4 appears to be a unique target for acetylation. Studies in yeast clearly indicate that acetylation of H4 lysine 16 is an independent specific function in relation to gene transcription when compared to other histone acetylation sites. It was also observed that a human histone acetyltransferase complex showed strong specificity for H4K16 in chromatin and, RNAi-mediated knockdown experiments revealed that it is responsible for the majority of H4 acetylation at lysine 16 in the cell.

Specifications

Chemistry
Sequence one letter code
  • SGRGKGGKGLGKGGA-K(Ac)-RHRK
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys(Ac)-Arg-His-Arg-Lys-OH
Molecular Mass/ Weight
  • 2034.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases

Biochem. . 2004 Jul 10 ; 43(30) 9877 | DOI : https://doi.org/10.1021/bi049592e

  • MT. Borra
  • et al