IMG-EN-AS-65209-1-01.jpg
Peptides

[Lys(Ac)16]-Histone H4 (1-25)-GSGSK(Biotin) - 1 mg

$431.00
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  • Cat.Number : AS-65209-1
  • Availability :
    In production

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This peptide is histone H4 (1-25) with acetylation at Lys16. It is biotinylated through a C-terminal GSGSK linker. Monoacetylation of histone H4 occurs predominantly at Lys16. Loss of monoacetylation at Lys16 is associated with human tumor cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • SGRGKGGKGLGKGGA-K(Ac)-RHRKVLRDN-GSGSK(Biotin)
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys(Ac)-Arg-His-Arg-Lys-Val-Leu-Arg-Asp-Asn-Gly-Ser-Gly-Ser-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 3274.9
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Acetylation of the Yeast Histone H4 N Terminus Regulates Its Binding to Heterochromatin Protein SIR3

J Biol Chem . 2002 Feb 01 ; 277(7) 4778 | DOI : https://doi.org/10.1074/jbc.M110532200

  • A. Carmen
  • et al

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Nat Genet . 2005 Mar 13 ; 37 391

  • M. Fraga
  • et al