IMG-EN-AS-65204-1-01.jpg
Peptides

[Lys(Ac)56]-Histone H3 (44-63) - 1 mg

$258.00
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  • Cat.Number : AS-65204-1
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    In stock

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This peptide is histone H3 (44-63) with acetylation at Lys56. Lys56 acetylation occurs during premeiotic and mitotic S phases and persists through DNA damage repair and is catalyzed by the Rtt109-Vps75 histone acetyltransferase (HAT) complex. A deficiency of acetylated Lys56 in histone H3 is implicated in spontaneous chromosome breaks during mitosis, suggesting that this modification is important for replisome integrity and DNA replication.

Specifications

Chemistry
Sequence one letter code
  • GTVALREIRRYQ-K(Ac)-STELLIR
Sequence three letter code
  • H-Gly-Thr-Val-Ala-Leu-Arg-Glu-Ile-Arg-Arg-Tyr-Gln-Lys(Ac)-Ser-Thr-Glu-Leu-Leu-Ile-Arg-OH
Molecular Mass/ Weight
  • 2445
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Acetylation of Lysine 56 of Histone H3 Catalyzed by RTT109 and Regulated by ASF1 Is Required for Replisome Integrity

J Biol Chem . 2007 Sep 01 ; 282(39) 28587 | DOI : https://doi.org/10.1074/jbc.M702496200

  • J. Han
  • et al

Rtt109 Is Required for Proper H3K56 Acetylation A CHROMATIN MARK ASSOCIATED WITH THE ELONGATING RNA POLYMERASE II

J Biol Chem . 2006 Dec 01 ; 281(49) 37270 | DOI : https://doi.org/10.1074/jbc.C600265200

  • J. Schneider
  • et al