[Lys(Ac)8]-Histone H4 (1-20) - 1 mg
- Cat.Number : AS-63684
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This is a histone 4 peptide acetylated at lysine 8. In some studies, this histone modification is thought to predict prognosis of resected non-small-cell lung cancer. This peptide has also been shown to play a role in somatic hypermutation (SHM) possible owing to its modification that likely mediates recruitment of error-prone DNA polymerases at the DNA repair stage of SHM.
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References
Epigenetics of the antibody response
Trends Immunol . 2013 Sep 01 ; 34(9) 460 | DOI : https://doi.org/10.1016/j.it.2013.03.006
- G. Li
- et al
Global Histone Modifications Predict Prognosis of Resected Non–Small-Cell Lung Cancer
J Clin Oncol . 2007 Oct 01 ; 25(28) 4358 | DOI : 10.1200/JCO.2007.11.2599
- F. Barlesi
- et al
Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases
Biochem. . 2004 Jul 10 ; 43(30) 9877 | DOI : https://doi.org/10.1021/bi049592e
- MT. Borra
- et al