Peptides

[Lys(Ac)9]-Histone H3 (1-24) - 1 mg

$195.00
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  • Cat.Number : AS-64453
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    In stock

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This Histone 3 peptide is acetylated at lysine residue at 9th position. In a glioblastoma xenograft expressing a O6-methylguanine-DNA methyltransferase (MGMT), increased H3K9-ac was observed in correlation to histone acetylation and MGMT upregulation, thus demonstrating a mechanism driven by chromatin-mediated MGMT upregulation in potentially directing epigenetic therapies to influence the mechanisms of resistance development in glioblastomas.

Specifications

Chemistry
Sequence one letter code
  • ARTKQTAR-K(Ac)-STGGKAPRKQLATKA
Sequence three letter code
  • H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Ac)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-OH
Molecular Formula
  • C109H198N40O33
Molecular Mass/ Weight
  • 2597.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts

Clin Can Res . 2012 Aug 01 ; 18(15) 4070 | DOI : 10.1158/1078-0432.CCR-12-0560

  • GJ. Kitange
  • et al