[Lys(Ac)9]-Histone H3 (1-24) - 1 mg
- Cat.Number : AS-64453
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This Histone 3 peptide is acetylated at lysine residue at 9th position. In a glioblastoma xenograft expressing a O6-methylguanine-DNA methyltransferase (MGMT), increased H3K9-ac was observed in correlation to histone acetylation and MGMT upregulation, thus demonstrating a mechanism driven by chromatin-mediated MGMT upregulation in potentially directing epigenetic therapies to influence the mechanisms of resistance development in glioblastomas.
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References
Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts
Clin Can Res . 2012 Aug 01 ; 18(15) 4070 | DOI : 10.1158/1078-0432.CCR-12-0560
- GJ. Kitange
- et al