Peptides

[Lys(Me3)27]-Histone H3 (23-34)-GGK(Biotin) - 1 mg

$227.00
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  • Cat.Number : AS-65397
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    In stock

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This is histone H3 (23-34) trimethylated at Lys27 and biotinylated on the C-terminus through a GGK linker. Trimethylation of Lys27 promotes Polycomb protein (Pc)-chromatin association. This modification has also been shown to be associated with methylated CpG island genes in cancer cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • KAAR-K(Me3)-SAPATGG-GGK(Biotin)
Sequence three letter code
  • H-Lys-Ala-Ala-Arg-Lys(Me3)-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Gly-Gly-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 1626
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation

Nat Struct Mol Biol . 2007 Sep 01 ; 14(9) 869 | DOI : 10.1038/nsmb1283

  • X. Zhang
  • et al

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

Nat Genet . 2007 Feb 01 ; 39(2) 232 | DOI : 10.1038/ng1950

  • Y. Schlesinger
  • et al

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

Genes Dev . 2003 Aug 01 ; 17(15) 1823 | DOI : 10.1101/gad.269603

  • J. Min
  • et al