[Lys(Me3)27]-Histone H3 (23-34)-GGK(Biotin) - 1 mg
- Cat.Number : AS-65397
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This is histone H3 (23-34) trimethylated at Lys27 and biotinylated on the C-terminus through a GGK linker. Trimethylation of Lys27 promotes Polycomb protein (Pc)-chromatin association. This modification has also been shown to be associated with methylated CpG island genes in cancer cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
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References
The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation
Nat Struct Mol Biol . 2007 Sep 01 ; 14(9) 869 | DOI : 10.1038/nsmb1283
- X. Zhang
- et al
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
Nat Genet . 2007 Feb 01 ; 39(2) 232 | DOI : 10.1038/ng1950
- Y. Schlesinger
- et al
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27
Genes Dev . 2003 Aug 01 ; 17(15) 1823 | DOI : 10.1101/gad.269603
- J. Min
- et al