IMG-EN-AS-65439-1-01.jpg
Peptides

[Lys(Me3)79]-Histone H3(73-83) - 1 mg

$138.00
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  • Cat.Number : AS-65439-1
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    In stock

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This peptide is Histone H3 amino acid residues 73 to 83 tri-methylated at Lysine 79. Histone lysine methylation plays a role in transcriptional regulation. H3K79 can be methylated by Dot1 methyltransferase.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EIAQDF-K(Me3)-TDLR
Sequence three letter code
  • H-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Me3)-Thr-Asp-Leu-Arg-OH
Molecular Mass/ Weight
  • 1378.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2

PNAS . 2012 Apr 17 ; 109(16) E916 | DOI : https://doi.org/10.1073/pnas.1121471109

  • P. Bheda
  • et al