pro-NPY peptide (34-43), human - 0.1 mg
- Cat.Number : AS-65602
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This peptide corresponds to host derived pro-NPY sequence with a cathepsin cleavage site. Host proteases, such as cathepsin L are involved in the processing and biosynthesis of neuropeptides including pro-NPY. In viral propagation, cathepsin mediated cleavage of viral proteins is necessary for cell entry, thereby affecting the host protein derived pro-NPY. The peptide is labeled with QXL®520 and 5-FAM as FRET pair and thus can serve as a substrate for investigation enzyme cleavage.
Neuropeptide Y (NPY) functions as a peptide neurotransmitter and as a neuroendocrine hormone. The active NPY peptide is generated in secretory vesicles by proteolytic processing of pro-NPY
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References
Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay
J Virol . 2014 Mar 26 ; 88(8) 4353 | DOI : https://doi.org/10.1128/JVI.03050-13
- H.A. Elshabrawy
- et al