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Peptides

[Pro19]-beta-Amyloid (1-42) - 1 mg

$482.00
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  • Cat.Number : AS-65178
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    In stock

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This peptide is beta-amyloid (1-42) with substitution of Phe19 to Pro. This substitution inhibits amyloid fibril formation, which is implicated in neurodegenerative diseases such as Alzheimer’s.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVPFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Pro-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Molecular Formula
  • C199H309N55O60S1
Molecular Mass/ Weight
  • 4464.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Amyloid β-Protein:  Monomer Structure and Early Aggregation States of Aβ42 and Its Pro19 Alloform

J Am Chem Soc . 2005 Jan 29 ; 127(7) 2075 | DOI : https://doi.org/10.1021/ja044531p

  • S. Bernstein
  • et al

Conformational Abs recognizing a generic amyloid fibril epitope

PNAS USA . 2002 Feb 05 ; 99(3) 1485 | DOI : https://doi.org/10.1073/pnas.022662599

  • B. O’Nuallain
  • R. Wetzel