IMG-EN-AS-60217-5-01.jpg
Peptides

Protease-Activated Receptor-2, PAR-2 Agonist 2, amide - 5 mg

$340.00
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  • Cat.Number : AS-60217-5
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This protease-activated receptor activating peptide (PAR-2-AP) corresponds to the PAR-2 tethered ligand.

Specifications

Chemistry
Sequence one letter code
  • SLIGKV-NH2
Sequence three letter code
  • H-Ser-Leu-Ile-Gly-Lys-Val-NH2
CAS registry number
  • 190383-13-2
Molecular Formula
  • C28H54N8O7
Molecular Mass/ Weight
  • 614.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.

Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch

Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells

Circ Res. . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch

Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2.

Mol Cancer Res. . 2008 Jun 01 ; 6(6) 1D46 | DOI : 10.1158/1541-7786.MCR-08-0096

  • G. Mize

References

Proteinase-Activated Receptor-2 and Human Lung Epithelial Cells

Am J Resp Call Mol Biol . 2002 Jun 07 ; 28(3) 339 | DOI : https://doi.org/10.1165/rcmb.4908  

  • S. Dulon
  • et al

Agonists of proteinase-activated receptor 2 induce TNF-αsecretion from astrocytoma cells

Cell Biochem Funct . 2002 Apr 23 ; 20(4) 339 | DOI : https://doi.org/10.1002/cbf.982

  • M. Kim
  • et al

Thrombin stimulates proinflammatory and proliferative responses in primary cultures of human proximal tubule cells

Kidney International . 2005 Apr 01 ; 67(4) 1315 | DOI : https://doi.org/10.1111/j.1523-1755.2005.00209.x

  • D. Vesey
  • et al

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

Can J Physiol Pharmacol . 1997 Jul 01 ; 75 832 | DOI : https://doi.org/10.1139/y97-110

  • M. Hollenberg
  • et al

Protease-Activated Receptor-2 (PAR-2)-Related Peptides Induce Tear Secretion in Rats: Involvement of PAR-2 and Non-PAR-2 Mechanisms

J Pharmacol Exp Ther . 2005 Jan 01 ; 312(1) 324 | DOI : https://doi.org/10.1124/jpet.104.072074

  • H. Nishikawa
  • et al