IMG-EN-AS-65490-01.jpg
Peptides

Protease-Activated Receptor-2, PAR-2 Agonist, amide - 1 mg

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  • Cat.Number : AS-65490
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The peptide 2-furoyl-LIGRLO-NH2 showed higher potency and receptor selectivity for in vitro assays than other PAR-2-activating peptides. 2-Furoyl-LIGRLO-NH2 peptide was equally or more potent than SLIGRL-NH2 for increasing intracellular calcium in cultured human and rat PAR-2-expressing cells and significantly more potent than SLIGRL-NH2 in assays of tissue PAR-2 activity.

Specifications

Chemistry
Sequence one letter code
  • 2-Furoyl-LIGRLO-NH2
Sequence three letter code
  • 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2
CAS registry number
  • 729589-58-6
Molecular Formula
  • C36H63N11O8
Molecular Mass/ Weight
  • 778
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

2-Furoyl-LIGRLO-amide: A Potent and Selective Proteinase-Activated Receptor 2 Agonist

J Pharmacol Exp Ther . 2004 Jun 01 ; 309(3) 1124 | DOI : https://doi.org/10.1124/jpet.103.064584

  • JJ. McGuire