IMG-EN-AS-62657-01.jpg
Peptides

Protease-Activated Receptor-3, PAR-3 (1-6), human - 1 mg

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  • Cat.Number : AS-62657
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This is amino acids 1 to 6 fragment of the protease-activated receptor 3 (PAR-3). This synthetic peptide induces ERK activation in human carcinoma cells endogeneously expressing PAR-1 and PAR-3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR-1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR-3 may mitigate the effects of PAR-1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression.

Specifications

Chemistry
Sequence one letter code
  • TFRGAP-NH2
Sequence three letter code
  • H-Thr-Phe-Arg-Gly-Ala-Pro-NH2
CAS registry number
  • 1872435-09-0
Molecular Formula
  • C29H46N10O7
Molecular Mass/ Weight
  • 646.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.

Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch

Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells

Circ Res. . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch

References

Proteinase-activated receptors (PARs)—the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1

Regul Pept . 2005 Feb 15 ; 125(1-3) 61 | DOI : https://doi.org/10.1016/j.regpep.2004.07.032

  • R. Kaufmann
  • et al

Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization

PNAS . 2007 Mar 27 ; 104(13) 5662 | DOI : https://doi.org/10.1073/pnas.0700763104

  • J. McLaughlin