Protease-Activated Receptor-3, PAR-3 (1-6), human - 1 mg
- Cat.Number : AS-62657
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This is amino acids 1 to 6 fragment of the protease-activated receptor 3 (PAR-3). This synthetic peptide induces ERK activation in human carcinoma cells endogeneously expressing PAR-1 and PAR-3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR-1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR-3 may mitigate the effects of PAR-1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression.
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Citations
Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.
Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8
- BH. Rauch
Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells
Circ Res. . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8
- BH. Rauch
References
Proteinase-activated receptors (PARs)—the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1
Regul Pept . 2005 Feb 15 ; 125(1-3) 61 | DOI : https://doi.org/10.1016/j.regpep.2004.07.032
- R. Kaufmann
- et al
Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
PNAS . 2007 Mar 27 ; 104(13) 5662 | DOI : https://doi.org/10.1073/pnas.0700763104
- J. McLaughlin