IMG-EN-AS-62938-01.jpg
Peptides

Protease-Activated Receptor-3, PAR-3 Agonist, amide - 1 mg

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  • Cat.Number : AS-62938
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    In stock

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PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.

Specifications

Chemistry
Sequence one letter code
  • SFNGGP-NH2
Sequence three letter code
  • H-Ser-Phe-Asn-Gly-Gly-Pro-NH2
CAS registry number
  • 261521-21-5
Molecular Formula
  • C25H36N8O8
Molecular Mass/ Weight
  • 576.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Protease activated receptor-1, but not -2, -3 and -4, is the player in the pathogenesis of atrial fibrosis; The experiment by neonatal rat atrial fibroblasts.

Int J Cardiol Heart Vessel.  . 2013 Nov 13 ; 2 21 | DOI : 10.1016/j.ijchv.2013.11.005

  • I. Keiichi

Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells.

Am J Physiol Lung Cell Mol Physiol. . 2009 Apr 10 ; 296(6) L979 | DOI : 10.1152/ajplung.90412.2008

  • AL. Firth

Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.

Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch

References

Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice

J Pharmacol Sci . 2008 Nov 06 ; 108(3) 385 | DOI : https://doi.org/10.1254/jphs.08200SC

  • K. Tsujii
  • et al

Protease-Activated Receptors in Cardiovascular Diseases

Circ . 2006 Sep 05 ; 114 1070 | DOI : https://doi.org/10.1161/CIRCULATIONAHA.105.574830

  • AJ. Leger