IMG-EN-AS-60778-01.jpg
Peptides

Protease-Activated Receptor-4, PAR-4 Agonist 3, amide, murine - 1 mg

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  • Cat.Number : AS-60778
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    In stock

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The family of seven transmembrane G protein coupled receptors includes at least four receptor subtypes (PAR1, PAR2, PAR3, PAR4). PAR4 activating peptides, GYPGKF-NH2 and AYPGKG-NH2, produce concentration dependent contractile effects on the muscle.

Specifications

Chemistry
Sequence one letter code
  • GYPGKF-NH2
Sequence three letter code
  • H-Gly-Tyr-Pro-Gly-Lys-Phe-NH2
CAS registry number
  • 245443-52-1
Molecular Formula
  • C33H46N8O7
Molecular Mass/ Weight
  • 666.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • murine

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References

Therapeutic expression of the platelet-specific integrin, αIIbβ3, in a murine model for Glanzmann thrombasthenia

Blood . 2005 Oct 15 ; 106(8) 2671 | DOI : https://doi.org/10.1182/blood-2004-12-4619

  • J. Fang
  • et al

Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon

Gut . 2004 Jan 14 ; 53(2) 229

  • F. Mulè

Protease-Activated Receptors (PARs) as Therapeutic Targets: Development of Agonists / Antagonists and Modulation of Gastrointestinal Functions

Drug Design Rev . 2004 Oct 01 ; 1(4) 287 | DOI : https://doi.org/10.2174/1567269043390663

  • F. Sekiguchi
  • et al

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides

JBC . 2000 Jun 01 ; 275(26) 19728 | DOI : https://doi.org/10.1074/jbc.M909960199

  • T. Faruqi
  • et al

PAR-4 Agonist AYPGKF Stimulates Thromboxane Production by Human Platelets

Arterioscler Thromb Vasc Biol . 2002 Mar 07 ; 22 861 | DOI : https://doi.org/10.1161/01.ATV.0000014742.56572.25

  • R. Henriksen
  • V. Hanks

Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney

Am J Physiol Renal Physiol . 2003 Jul 01 ; 285 95 | DOI : https://doi.org/10.1152/ajprenal.00396.2002

  • Y. Gui
  • et al