IMG-EN-AS-29907-01-01.jpg
Peptides

[Pyr3]-beta-Amyloid (3-42)

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  • Cat.Number : AS-29907-01
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This is one of the predominant amyloid peptide structures deposited in human brain of Alzheimer’s disease and Down’s syndrome patients. N-terminally truncated pyroglutamate-modified beta-Amyloid forms such as Aß(3-42) and Aß (11- 42) have been described as major compounds in the senile plaques. Pyro-Glu modified beta-Amyloid forms are more resistant to degradation, show higher toxicity and have increased aggregation propensity compared to non-modified beta-Amyloid.

Specifications

Chemistry
Sequence one letter code
  • Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS registry number
  • 183449-57-2
Molecular Formula
  • C196H299N53O55S
Molecular Mass/ Weight
  • 4309.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

J Neural Transm . 2010 Jan 01 ; 117(1) 85 | DOI : 10.1007/s00702-009-0314-x

  • O. Wirths

N‐terminal truncated pyroglutamyl β amyloid peptide Aβpy3‐42 shows a faster aggregation kinetics than the full‐length Aβ1‐42.

Biopolymers . 2009 Oct 01 ; 91(10) 861 | DOI : 10.1002/bip.21271

  • C. D'Arrigo

Effect on memory of acute administration of naturally secreted fibrils and synthetic amyloid-beta peptides in an invertebrate model.

Neurobiol Learn Mem . 2007 Oct 24 ; 89(4) 407 | DOI : 10.1016/j.nlm.2007.08.011

  • M. Feld

β-Amyloid is different in normal aging and in Alzheimer disease.

J. Biol. Chem. . 2015 Aug 15 ; 280(40) 34186 | DOI : 10.1074/jbc.M501694200

  • A. Piccini

References

Presenilin-1 mutations in Alzheimer's disease

Neurobiol Nature . 2000 Jun 01 ; 405 531 | DOI : https://doi.org/10.1038/35014735

  • C. Russo
  • et al