Peptides

Tat-C (48-57) - 1 mg

  • Cat.Number : AS-62063
  • Availability :
    In stock

Quantity

This peptide is amino acids 48 to 57 fragment of TAT with an additional cysteine residue at the N-terminus. This peptide contains the protein transduction domain (PTD) of the HIV Tat protein that inhibits HSV-1 entry. The addition of a cysteine residue to the N-terminus of the Tat-PTD (Tat-C peptide) improves the antiviral activity against HSV-1 and HSV-2. Tat-C acts extracellularly, blocking entry of adsorbed virus immediately without eluting virions.

Specifications

Chemistry
Sequence one letter code
  • CGRKKRRQRRR
Sequence three letter code
  • H-Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH
CAS registry number
  • 627079-23-6
Molecular Formula
  • C58H114N32O13S
Molecular Mass/ Weight
  • 1499.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • HIV

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Citations

Virus-mimetic polymeric micelles for targeted siRNA delivery

Biomaterials.  . 2010 Apr 27 ; 31(22) 5886 | DOI : 10.1016/j.biomaterials.2010.03.075

  • X. Xiong

References

Addition of a C-terminal cysteine improves the anti-herpes simplex virus activity of a peptide containing the human immunodeficiency virus type 1 TAT protein transduction domain.

Antimicrob Agents Chemother. . 2007 Jan 29 ; 51(5) 1596 | DOI : 10.1128/AAC.01009-06

  • H. Bultmann
  • et al