IMG-EN-AS-64429-01.jpg
Peptides

Tat-GluR23Y - 1 mg

$141.00
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  • Cat.Number : AS-64429
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The synthetic peptide (Tat-Glur23Y) contains tyrosine residues that blocks phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Previous research shows that Tat-Glur23Y blocks regulated AMPA and thereby prevents long-term depression (LTD) in structures such as the nucleus accumbens and dorsal hippocampus.

Specifications

Chemistry
Sequence one letter code
  • YGRKKRRQRRRYKEGYNVYG
Sequence three letter code
  • H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH
Molecular Formula
  • C115H185N43O29
Molecular Mass/ Weight
  • 2634.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • HIV

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Citations

Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior.

Learn. Mem . 2012 Jan 01 ; 19 307 | DOI : 10.1101/lm.025148.111

  • WM. Pauli

Inhibition of PKMζ in nucleus accumbens core abolishes long-term drug reward memory

J Neurosci. . 2011 Apr 06 ; 31(14) 5436 | DOI : 10.1523/JNEUROSCI.5884-10.2011

  • Y. Li

References

Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear.

Neuropsychopharma . 2007 Nov 28 ; 33(10) 2416 | DOI : 10.1038/sj.npp.1301642

  • G. Dalton
  • et al

Amygdala depotentiation and fear extinction

PNAS . 2007 Dec 26 ; 104(52) 20955 | DOI : https://doi.org/10.1073/pnas.0710548105

  • J. Kim
  • et al