Tat-GluR23Y, scrambled - 1 mg
- Cat.Number : AS-64428
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Tat-Glur23Y, scrambled is a control peptide. The synthetic peptide (Tat-Glur23Y), containing tyrosine residues, blocks phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. However, the scrambled version does not have blockade properties. Previous studies show that Tat-Glur23Y, scrambled increase stress levels in mice, while Tat-Glur23Y reduces stress when administered.
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Citations
Inhibition of PKMζ in nucleus accumbens core abolishes long-term drug reward memory
J Neurosci. . 2011 Apr 06 ; 31(14) 5436 | DOI : 10.1523/JNEUROSCI.5884-10.2011
- Y. Li
References
Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear.
Neuropsychopharma . 2007 Nov 28 ; 33(10) 2416 | DOI : 10.1038/sj.npp.1301642
- G. Dalton
- et al
Amygdala depotentiation and fear extinction
PNAS . 2007 Dec 26 ; 104(52) 20955 | DOI : https://doi.org/10.1073/pnas.0710548105
- J. Kim
- et al