Custom Peptide Synthesis
Chelating Peptide
Manufacturing
Accelerate the development of radiopharmaceuticals and assays with custom chelating peptides, whether linear or cyclic. We deliver precision manufacturing with your chosen chelator and linker.
Millgram to Grams
We recognize that flexibility in production scale is important at every stage of your project.
Bench to Clinic
Up to 95% purity for research grade and 98% for GMP API starting materials and precursors.
Cyclic or Linear
We offer a full panel of cyclization strategies and modifications to optimize your targeting peptide.
Chelator & Linker Options
AnaSpec offers a broad selection of chelators and linkers carefully chosen to support efficient
radiolabeling and stable conjugation. We gladly accommodate custom chelators
or other starting materials to meet your specific requirements. Below are just a few chelator examples.
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DOTA (amide)
1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid
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DOTA (thiourea)
1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid
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NOTA (amide)
1,4,7-triazacyclononane-N,N′,N′′triacetic acid
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NODAGA (amide)
1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane
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DTPA (amide)
N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-glycine
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DTPA (thioether)
N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-glycine
Linkers
Linkers can be placed between the targeting peptide and chelator to
improve solubility
and/or prevent stearic hindrance. Below are a few linker examples.
| Linker | Name | Structure |
|---|---|---|
| B-alanine | beta-alanine |  |
| GABA | 4-aminobutyric acid |  |
| AHX or LC (Long-chain linker) |
6-aminohexanoic acid ε-aminocaproic acid |
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| PEG2-CH2COOH | Polyethylene glycol 2-[2-(2-aminoethoxy)ethoxy)acetic acid |
 |
| PEG2-CH2CH2COOH | Polyethylene glycol 3-(2-(2-aminoethoxy)ethoxy)propionic acid |
 |
Key Applications
FAQ
Can my chelating peptide be cyclic?
Yes, AnaSpec manufactures linear or cyclic targeting peptides and offers many cyclization strategies to suite your your needs.
Can you further modify my targeting peptide with unusual or non-canonical amino acids?
Yes, AnaSpec offers an array of unusual non-canonical amino acids and building blocks to further modify your targeting peptide sequence for improved stability and specificity.
Can my proprietary chelator and/or linker be used to produce my peptide?
Yes. AnaSpec can use your proprietary molecules to produce your peptide with the assurance that your IP is protected.
Do you radiolabel chelating peptides?
No. We do not handle radioactivity at our facility. However, we can perform cold isotope labeling for use in standards, and label with lanthanide metals for TR-FRET substrates.
Featured Citations
Using Integrin αvβ6-Targeted Positron Emission Tomography Imaging to Longitudinally Monitor Radiation-Induced Pulmonary Fibrosis In Vivo
Lo, William C.Y. et al.
International Journal of Radiation Oncolcology 121 (2025) 484–492 DOI 10.1016/j.ijrobp.2024.08.034
DOTA-PEGylated peptide was synthesized by AnaSpecOrgan biodistribution of Germanium-68 in rat in the presence and absence of [68Ga]Ga-DOTA-TOC for the extrapolation to the human organ and whole-body radiation dosimetry
Velikyan, I., Antoni, G., Sörensen, J. & Estrada, S.
Am J Nucl Med Mol Imaging 3 (2013) 154–165 PMID: 2352648
DOTA-TOC was produced by AnaspecCyclic 68Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2
Parker, M. F. L. et al.
J. Nucl. Med. 62 (2021) 1631–1637 DOI 10.2967/jnumed.120.261768
DOTA-PEGylated peptide was synthesized by AnaSpecTherapeutic Efficacy of 177Lu-Labeled A20FMDV2 Peptides Targeting ανβ6
Huynh, T. T., Sreekumar, S., Mpoy, C. & Rogers, B. E.
Pharmaceuticals (Basel), 15(2) (2022) 229. DOI 10.3390/ph15020229
DOTA-PEGylated peptide was synthesized by AnaSpec
