[Trp63, 64]-C3a (63-77) - 1 mg
- Cat.Number : AS-61119
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This peptide, which is a C-terminal analogue of the complement factor C3a, acts as an agonist to the C3a receptor. It is derived from the fifteen C-terminal residues (6-77) of C3a. In in vitro studies, both C 3a and this peptide have been shown to selectively bind to C3aRs and induce degranulation of C3aR-transfeted RBL-2H3 cells. There was also a rapid, transient and concentration-dependent hypertensive response observed in rats when infused intravenously with C3a and this peptide.
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Citations
Parallel detection of intrinsic fluorescence from peptides and proteins for quantification during mass spectrometric analysis
Anal Chem . 2011 Mar 15 ; 83(6) 2187 | DOI : 10.1021/ac103023q
- J. Russell
References
Complement factors C3a and C5a have distinct hemodynamic effects in the rat
Intl Immunopharmacol . 2009 Jun 01 ; 9(6) 800
- LM. Proctor
- et al
Evidence that the receptor for C4a is distinct from the C3a receptor
Immunopharmacol . 1997 Dec 01 ; 38(1-2) 87 | DOI : https://doi.org/10.1016/S0162-3109(97)00079-9
- R. Ames
- et al