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Peptides  >  Thrombin Related Peptides  >>  Protease-Activated Receptor-4, PAR-4 Agonist, amide

Product Name Protease - Activated Receptor - 4, PAR - 4 Agonist, amide
Size 5 mg
Catalog # AS-60218-5
US$ $264
Purity % Peak Area By HPLC ≥ 95%

PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005).
Molecular Weight 680.8
(One-Letter Code)
(Three-Letter Code)
H - Ala - Tyr - Pro - Gly - Lys - Phe - NH2
Product Citations Naik, M.U. et al. (2009). CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3 J Thrombosis Haemostasis 7 doi: 10.1111/j.1538-7836.2009.03581.x.
Lindsey, S. et al. (2014). Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling J Thrombosis Haemostasis 12 doi: 10.1111/jth.12490.
Naik, M. U. et al. (2012). JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets blood119 doi: 10.1182/blood-2011-12-397398.
Patil, S.B. et al. (2010). Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima Am Heart Assoc doi: 10.1161/ATVBAHA.110.210732.
Panicot-Dubois, L. et al. (2007). Bile salt–dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans J Clinical Invest doi: 10.1172/JCI32655.
Erhard, J.A. et al. (2006). P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation J Thrombosis Haemostasis4 doi: 10.1111/j.1538-7836.2006.01849.x.
Rauch, B. H. et al. (2003) Thrombin- and factor Xa–Induced DNA synthesis Is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells Am Heart Assoc doi: 10.1161/01.RES.0000111805.09592.D8.
Murad, JP. et al. (2012). Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan J Cardiovasc Pharmacol Ther 17 308. doi: 10.1177/1074248411425491.
Su, X. et al.(2005) Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms 1J Immunol 175 doi: 10.4049/​jimmunol.175.4.2598.
Kataoka, H. et al. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells Blood 102 doi: 10.1182/blood-2003-04-1130.
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