IMG-EN-AS-60023-1-01.jpg
Peptides

TAT (47-57) Peptide Fragment

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  • Cat.Number : AS-60023-1
  • Availability :
    In production

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This is the most characterized fragment of the HIV transactivator protein (TAT). This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis.

Specifications

Chemistry
Sequence one letter code
  • YGRKKRRQRRR
Sequence three letter code
  • H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH
CAS registry number
  • 191936-91-1
Molecular Formula
  • C64H118N32O14
Molecular Mass/ Weight
  • 1559.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • HIV

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Citations

Penetratin improves tumor retention of single-chain antibodies: A novel step toward optimization of radioimmunotherapy of solid tumors.

Cancer Res . 2005 Sep 01 ; 65(17) 7840 | DOI : 10.1158/0008-5472.CAN-05-0662.

  • M. Jain

Resolving rotational motions of nano-objects in engineered environments and live cells with gold nanorods and differential interference contrast microscopy

J Am Chem Soc.  . 2010 Nov 02 ; 132(46) 16417 | DOI : 10.1021/ja106506k

  • G. Wang

Identification of a Novel Sodium-Coupled Oligopeptide Transporter (SOPT2) in Mouse and Human Retinal Pigment Epithelial Cells

Invest Ophthalmol Vis Sci. . 2010 Jan 01 ; 51(1) 413 | DOI : 10.1167/iovs.09-4048

  • P. Chothe

Wavelength-dependent differential interference contrast microscopy: selectively imaging nanoparticle probes in live cell

Anal Chem. . 2009 Nov 15 ; 81(22) 9203 | DOI : 10.1021/ac901623b

  • W. Sun

A Novel Class of Fusion Polypeptides Inhibits Exocytosis

Mol Pharmacol. . 2004 Dec 17 ; 67(4) 1137 | DOI : 10.1124/mol.104.004275

  • K. Matsushita

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

Biochem J.  . 2011 Apr 15 ; 435(2) 475 | DOI : 10.1042/BJ20101021

  • R. Bartz

References

Induction of CD4+ T cell–dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells

J Clin Invest . 2002 Jun 01 ; 109(11) 1463 | DOI : 10.1172/JCI15399

  • H. Wang
  • et al

The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence.

Biochemistry.  . 2005 Jan 11 ; 44(1) 138 | DOI : 10.1021/bi0491604

  • A. Ziegler
  • et al