Amylin (22-27) [NMeG24, NMeI26], human (IAPP) - 1 mg
- Cat.Number : AS-61937
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This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.
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References
Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis
PNAS . 2006 Feb 14 ; 103(7) 2046 | DOI : https://doi.org/10.1073/pnas.0507471103
- L. Yan
- et al
Inhibition of hIAPP Amyloid-Fibril Formation and Apoptotic Cell Death by a Designed hIAPP Amyloid- Core-Containing Hexapeptide
Cell Press . 2005 Jul 01 ; 12(7) 797 | DOI : https://doi.org/10.1016/j.chembiol.2005.05.010
- M. Tatarek-Nossol
- et al
Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity
J. Mol. Biol. . 2002 Jan 18 ; 315(3) 339 | DOI : https://doi.org/10.1006/jmbi.2001.5244
- A. Kapurniotu
- et al