IMG-EN-AS-62639-01.jpg
Peptides

37, 40Gap 26, Connexin Mimetic - 1 mg

$110.00
Check your price
  • Cat.Number : AS-62639
  • Availability :
    In stock

Quantity

Add to wishlist Bulk Quote

This peptide corresponds to the GAP26 domain of the extracellular loop of the major vascular connexins (Cx37, Cx40), designated as 37,40Gap 26 according to Cx homology. It was used to investigate the role of gap junctions in the spread of endothelial hyperpolarizations evoked by cyclopiazonic acid (CPA) through the wall of the rodent iliac artery. The gap junction plaques constructed from Cx37 and Cx40 were abundant in the endothelium. This peptide provides inhibitory effects against subintimal hyperpolarization.

Specifications

Chemistry
Sequence one letter code
  • VCYDQAFPISHIR
Sequence three letter code
  • H-Val-Cys-Tyr-Asp-Gln-Ala-Phe-Pro-Ile-Ser-His-Ile-Arg-OH
Molecular Formula
  • C70H105N19O19S1
Molecular Mass/ Weight
  • 1548.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat, bovine

Downloads

You may also be interested in the following product(s)

IMG-EN-AS-62641-01.jpg

40Gap 27, Connexin Mimetic - 1 mg

Cat.Number : AS-62641
$103.00 Excl. Tax
IMG-EN-AS-62642-01.jpg

43Gap 27, Connexin (200-210) (human, mouse, rat) - 1 mg

Cat.Number : AS-62642
$103.00 Excl. Tax
IMG-EN-AS-62644-01.jpg

Gap 26, Connexin 43 (63-75) (human, mouse, rat, bovine) - 1 mg

Cat.Number : AS-62644
$110.00 Excl. Tax

Citations

Pregnancy Enhances Sustained Ca2+ Bursts and Endothelial Nitric Oxide Synthase Activation in Ovine Uterine Artery Endothelial Cells Through Increased Connexin 43 Function.

Biol Reprod . 2009 Sep 09 ; 82(1) 66 | DOI : 10.1095/biolreprod.109.078253

  • FX. Yi

References

Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery

British J Pharmacol . 2005 Jan 29 ; 144(1) 108 | DOI : https://doi.org/10.1038/sj.bjp.0706046

  • A. Chaytor
  • et al