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Fluorescent Dyes  >  Fluorescent Biopolymers  >>  Beta-Amyloid (1-16), Human

Product Name Beta - Amyloid (1 - 16), Human
Size 1 mg
Catalog # AS-24225
US$ $85
Purity % Peak Area By HPLC ≥ 95%

Proteins interactions with reactive oxygen agents may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages and oxidation of the protein backbone resulting in protein fragmentation. Oxidation targets for Aß(1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aß in senile plaque of Alzheimer’s disease with Aß (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of Aß and free radical damage.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Da Silva, GFZ. et al. J. Biol. Chem. 280, 16601 (2005); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 98, 940 (2004); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 95, 270 (2003).
Molecular Weight 1955.1
(One-Letter Code)
(Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - OH
Product Citations Miller, A. et al. (2011). Behavior of β-amyloid 1-16 at the air-water interface at varying pH by nonlinear spectroscopy and molecular dynamics simulations. J Phys Chem 10.1021/jp110103j.

Minicozzi, V. et al. (2008). Identifying the minimal Cu and Zn binding site sequence in amyloid beta peptides. J Biol Chem 10.1074/jbc.M707109200.

Solorzano-Vargas, R.S. et al. (2008). Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42. Mol Immunol 45, 881.

Osada, Y. et al. (2004). CLAC binds to amyloid β peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280, 8596.

Cottingham, MG. et al. (2004). Rapid method for measurement of surface tension in multiwell plates. Lab Methods 84, 523.
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