IMG-EN-AS-61530-01.jpg
Peptides

Protease-Activated Receptor-1, PAR-1 Agonist - 1 mg

$85.00
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  • Cat.Number : AS-61530
  • Availability :
    In stock

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Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation

Specifications

Chemistry
Sequence one letter code
  • TFLLRN
Sequence three letter code
  • H-Thr-Phe-Leu-Leu-Arg-Asn-OH
Molecular Formula
  • C35H58N10O9
Molecular Mass/ Weight
  • 762.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells.

Am J Physiol Lung Cell Mol Physiol. . 2009 Apr 10 ; 296(6) L979 | DOI : 10.1152/ajplung.90412.2008

  • AL. Firth

Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.

Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch

Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth

J Biol Chem. . 2014 Mar 20 ; 289(19) 13295 | DOI : 10.1074/jbc.M114.550541

  • H. Mogami

Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1

Cancer Res . 2009 Mar 17 ; 69(7) 3188 | DOI : 10.1158/0008-5472.CAN-08-1956

  • TJ. Wilson

Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury

J Clin Invest. . 2006 May 18 ; 116(6) 1606 | DOI : 10.1172/JCI27183

  • RG. Jenkins

Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells

Circ Res. . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch

Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells

Blood . 2003 Jul 17 ; 102(9) 3224 | DOI : 10.1182/blood-2003-04-1130

  • H. Kataoka

References

Cyclooxygenase-2 Induction and Prostacyclin Release by Protease-activated Receptors in Endothelial Cells Require Cooperation between Mitogen-activated Protein Kinase and NF-κB Pathways

JBC . 2006 Apr 01 ; 281(17) 11792 | DOI : https://doi.org/10.1074/jbc.M509292200

  • F. Syeda
  • et al

Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury

J Clin Invest . 2006 Jun 01 ; 116(6) 1606 | DOI : 10.1172/JCI27183

  • RG. Jenkins
  • et al