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Peptides  >  Thrombin Related Peptides  >>  Protease-Activated Receptor-1, PAR-1 Agonist
Product Name Protease - Activated Receptor - 1, PAR - 1 Agonist
TFLLRN
Size 1 mg
Catalog # AS-61530
US$ $61
Purity % Peak Area By HPLC ≥ 95%
Description

This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation
Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Ref: Syeda,, F. et al. J. Biol. Chem 281, 11792 (2006); Jenkins, R. et al. J. Clin. Invest; 116, 1606 (2006).
Molecular Weight 762.9
Sequence
(One-Letter Code)		 TFLLRN
Sequence
(Three-Letter Code)		 H - Thr - Phe - Leu - Leu - Arg - Asn - OH
Product Citations Mogami, H. et al. (2014). Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J Biol Chem 289, 13295. doi: 10.1074/jbc.M114.550541.

Firth, AL. et al. (2009). Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 296, L979.

Wilson, TJ. et al. (2009). Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.Cancer Res. 69, 3188.

Jenkins, RG. et al. (2006). Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury J. Clin. Invest. 116, 1606.

Rauch, BH. et al. (2004). Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ. Res. 94, 340.

Kataoka, H. et al. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood 102, 3224.
     
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