Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Stay Logged In

Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Thrombin Related Peptides  >>  Protease-Activated Receptor-1, PAR-1 Agonist

Product Name Protease - Activated Receptor - 1, PAR - 1 Agonist
Size 1 mg
Catalog # AS-61530
US$ $61
Purity % Peak Area By HPLC ≥ 95%

This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Ref: Syeda,, F. et al. J. Biol. Chem 281, 11792 (2006); Jenkins, R. et al. J. Clin. Invest; 116, 1606 (2006).
Molecular Weight 762.9
(One-Letter Code)
(Three-Letter Code)
H - Thr - Phe - Leu - Leu - Arg - Asn - OH
Product Citations Mogami, H. et al. (2014). Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J Biol Chem 289, 13295. doi: 10.1074/jbc.M114.550541.

Firth, AL. et al. (2009). Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 296, L979.

Wilson, TJ. et al. (2009). Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.Cancer Res. 69, 3188.

Jenkins, RG. et al. (2006). Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury J. Clin. Invest. 116, 1606.

Rauch, BH. et al. (2004). Thrombin and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ. Res. 94, 340.

Kataoka, H. et al. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood 102, 3224.
  < Back