This peptide sequence represents a furin-like cleavage site of the Spike (S) protein of the SARS-CoV-2 virus. The S protein must be likely cleaved at two sites, S1/S2 and S2 for viral entry into host cell. The sequence at the S1/S2 junction which contains a polybasic cleavage site (RR↓AR) represents the first cleavage site. This peptide has been labeled with QXL®520 and 5-FAM.
Coutard B, et al. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742.
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Thr - Asn - Ser - Pro - Arg - Arg - Ala - Arg - Ser - Val - Ala - Ser - Lys(5 - FAM) - OH