Peptides

Calpain Substrate Suc-LLVY-AMC, fluorogenic substrate - 5 mg

$110.00
Check your price
  • Cat.Number : AS-63892
  • Availability :
    In stock

Alternative choices

Quantity

Calpains are a family of intracellular Ca2+ dependent cysteine proteases. They respond to Ca2+ signals by cleaving many specific proteins, thereby irreversibly modifying their function(s). They are implicated in a variety of Ca2+ regulated cellular processes as well as various pathological phenomena, such as ischemic injury, muscular dystrophy, diabetes, cataract, atherosclerosis, Alzheimer’s disease, and cancer. Calpains represent potential therapeutic targets for drug discovery.
This 7-amino-4-methylcoumarin (AMC) labeled peptide is widely used as a fluorogenic substrate for 20S proteasome, calpains and other chymotrypsin-like proteases. Cleavage of this AMC peptide by the enzymes generates strongly fluorescent AMC that is monitored fluorimetrically at Abs/Em=353/442 nm.

Specifications

Chemistry
Sequence one letter code
  • Suc-LLVY-AMC
Sequence three letter code
  • Suc-Leu-Leu-Val-Tyr-AMC
CAS registry number
  • 94367-21-2
Molecular Formula
  • C40H53N5O10
Molecular Mass/ Weight
  • 763.9
Properties
Absorbance (nm)
  • 353
Emission (nm)
  • 442
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

You may also be interested in the following product(s)

IMG-EN-AS-60844-01.jpg

Calpain Inhibitor Peptide, B27-WT - 0.5 mg

Cat.Number : AS-60844
$147.00 Excl. Tax
IMG-EN-AS-72149-01.jpg

SensoLyte® 520 Calpain Activity Assay Kit Fluorimetric - 1 kit

Cat.Number : AS-72149
$621.00 Excl. Tax
IMG-EN-AS-72150-01.jpg

SensoLyte® AMC Calpain Activity Assay Kit Fluorimetric - 1 kit

Cat.Number : AS-72150
$615.00 Excl. Tax

Citations

Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease

J Biol Chem. . 2011 Jan 28 ; 286(12) 10457 | DOI : 10.1074/jbc.M110.149633

  • E. Dammer

The JAMM motif of human deubiquitinase Poh1 is essential for cell viability

Mol Cancer Ther. . 2007 Jan 01 ; 6(1) 262 | DOI : 10.1158/1535-7163.MCT-06-0542

  • M. Gallery