Assay-kits

SensoLyte® Fluorescent ß-Amyloid (1-42) Sampler Kit - 1 kit

$456.00
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  • Cat.Number : AS-72071
  • Availability :
    In stock
  • Shipping conditions : Ice fees will apply

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Fluorophore labeled beta-amyloid peptides have been used in investigating beta-amyloid's aggregation, generation and clearance, microglial activation and phagocytosis. The SensoLyte® Fluorescent beta-Amyloid (1-42) Sampler Kit provides three fluorescent beta-amyloid (1-42) peptides, two unlabeled control peptides and biotin labeled beta-amyloid (1-42) peptide. The sampler kit provides ample choices for researchers interested in beta-amyloid related experiments

Alzheimer's Disease (AD) is the most common neurodegenerative disorder in elderly people. It has been demonstrated that AD has biological causes and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. Beta-Amyloid (1-40) (Aα40) and beta-Amyloid (1-42) (Aα42) are the main components of the above plaques; however, other forms of beta-Amyloid peptides are also present. Both peptides are cleaved from the Amyloid Precursor Protein (APP) by α-secretase and γ-secretase enzymes. Many studies suggest that Aα42 or/and Aα43 are required to initiate formation of amyloid plaques and neurofibrills that leads to the neurodegeneration, while Aα40 is less neurotoxic.

Specifications

Packaging
Kits components
  • Component A: 6 peptides (each as lyophilized powder): - Two unlabeled control peptides: AS-24224 (ß-amyloid 1-42), AS-25382 (scrambled ß-amyloid 1-42) - A biotin labeled ß-amyloid 1-42 peptide: AS-23524 (biotin-ß-amyloid 1-42) - Three ß-amyloid 1-42 peptides with different fluorophore conjugates: AS-23526 (FAM-ß-amyloid 1-42; 494/521nm); AS-60479 (HiLyte™ Fluor 488-ß-amyloid 1-42; 503/528nm); AS-60476 (TAMRA-ß-amyloid 1-42; 544/572nm) Component B: Solvent for ß-amyloid 1-42 (1 mL)
Chemistry
UniProt number
  • P05067
Properties
Absorbance (nm)
  • 494/503/544
Emission (nm)
  • 521/528/572
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • Store all peptides (Component A) at -20°C. Keep peptides (Component A) away from light and protect from moisture. Component B may be kept at 4°C.
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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