Protein

DJ-1 (PARK7), human recombinant

$110.00
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  • Cat.Number : AS-72219-10
  • Availability :
    In stock
  • Shipping conditions : Ice fees will apply

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Size

Quantity

DJ-1 (also known as PARK7, Parkinson disease protein 7) is a 189 amino acids protein that is ubiquitously expressed in many organs including brain, liver, kidney, pancreas, heart, and others . Although DJ-1 was originally discovered as a novel oncogene product, it was found to play several other roles in biological processes. They include regulation of RNA binding activity, fertility, anti-oxidative stress, and linked to the early onset of Parkinson's disease when mutated.

Sequence (Accession# NP_001116849) corresponds to the full length human DJ-1 protein and was expressed in E. coli.

Specifications

Chemistry
UniProt number
  • Q99497
Molecular Mass/ Weight
  • 19.9 kDa
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Purification Method
  • Purified
Purity
  • ≥95% by SDS-PAGE
Storage & stability
Form
  • In solution
Storage Buffer
  • 50 mM Tris-HCl/150mM NaCl, pH=8.0
Storage Conditions
  • Store at -80°C. Avoid repeated freeze-thaw cycles.
Activity
Application
Biomarker Target
Specificity
  • full length human DJ-1
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human

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References

Crystal structure of DJ-1/RS and implication on familial Parkinson’s disease

FEBS Letters . 2003 Aug 14 ; 549(1-3) 171 | DOI : https://doi.org/10.1016/S0014-5793(03)00764-6

  • Q. Huai
  • et al

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

PNAS . 2007 Jul 30 ; 104(37) 14807 | DOI : https://doi.org/10.1073/pnas.0703219104

  • E. Andres-Mateos
  • et al

Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats

Mol Neurodeg . 2011 Jul 08 ; 6(1) 48 | DOI : 10.1186/1750-1326-6-48

  • Y. Kitamura
  • et al

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

Hum Mol Genetics . 2010 Jun 15 ; 19(12) 2395 | DOI : https://doi.org/10.1093/hmg/ddq113

  • J. Chen
  • et al

Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7

J of Pharma Sci . 2011 Oct 29 ; 117(3) 189 | DOI : 10.1254/jphs.11151fp

  • M. Inden
  • et al