Protein

Human recombinant b-Synuclein (1-134)

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  • Cat.Number : AS-55458-100
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    In stock
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Beta-synuclein belongs to the family of highly conservative proteins in vertebrates. N-terminal of β-synuclein is highly homologous to α-, γ-synucleins and consists of degenerative “KTKEGV” repeats. Similar to α-synuclein, beta-synuclein is found primarily in the brain; however, it does not associate with Lewy bodies in Parkinson disease like α-synuclein. Beta-synuclein was found to inhibit production of phosphatidic acid by the phospholipase D2 transmembrane protein in vitro. In addition, beta-synuclein was detected in many breast and ovarian tumors. Recent investigations demonstrated that beta-synuclein can induce mild experimental autoimmune encephalomyelitis (EAE) in Lewis rats

The sequence (Accession # NP_003076) corresponding to the human β-synuclein along with a 6x His tag was expressed in E. coli.

Specifications

Chemistry
UniProt number
  • Q16143
Molecular Mass/ Weight
  • ~18 kDa on SDS-PAGE
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Purification Method
  • Purified
Purity
  • >90%
Storage & stability
Form
  • In solution
Storage Buffer
  • 20 mM Tris-HCl, 0.1 M NaCl, 1 mM MgCl2, pH 7.5
Storage Conditions
  • Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for up to 6 months. Avoid repeated freeze-thaw cycles.
Activity
Application
Biomarker Target
Specificity
  • human ß-synuclein (1-134)
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human

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