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Recombinant Proteins  >  α-Synuclein & β-Synuclein  >>  Recombinant Human β-Synuclein (1-134)

Product Name Recombinant Human β - Synuclein (1 - 134)
Size 1 mg
Catalog # AS-55458-1000
US$ $420
Purity Greater than 90% as determined by SDS-PAGE.

The sequence (Accession # NP_003076)) corresponding to the human β-synuclein along with a 6x His tag was expressed in E. coli.

Endotoxin (EU/μg): Less than 1 EU per 1 μg of the protein as determined by Limulus Amebocyte Lysate (LAL) quantitative kinetic assay.

Beta-synuclein belongs to the family of highly conservative proteins in vertebrates. N-terminal of β-synuclein is highly homologous to α-, γ-synucleins and consists of degenerative “KTKEGV” repeats (1-4). Similar to α-synuclein, beta-synuclein is found primarily in the brain; however, it does not associate with Lewy bodies in Parkinson disease like α-synuclein (1-4). Beta-synuclein was found to inhibit production of phosphatidic acid by the phospholipase D2 transmembrane protein in vitro (1). In addition, beta-synuclein was detected in many breast and ovarian tumors (4). Recent investigations demonstrated that beta-synuclein can induce mild experimental autoimmune encephalomyelitis (EAE) in Lewis rats (5).

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Images Recombinant Human β-Synuclein (1-134)
Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage Purified human β-synuclein is supplied as sterile and frozen at 1 mg/ml in the following buffer: 20 mM Tris-HCl, 0.1 M NaCl, 1 mM MgCl2, pH 7.5. Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for up to 6 months. Avoid repeated freeze-thaw cycles.
References 1.     Rivers R.C. et. al. (2008) Protein Science 17: 887-898
2.     Sung Y.-H. et. al. (2006) Protein Science 15: 1162-1174
3.     George J. M. (2001) Genome Biology 3 (1): 3002.1-3002.6
4.     Bruening W. et. al. (2000) American Cancer Society 88 (9): 2154-216
5.     Kela-Madar N. et. al. (2009) Journal of Neuroimmunology 208: 19-29
Molecular Weight 18 kDa
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