Apelin-12, one of the most potent apelin peptides, lowers blood pressure via a nitric oxide-dependent mechanism. It is also involved in the central control of feeding by stimulating cholecystokinin (CCK) secretion.
Ref: O’Shea, M. et al. Nutr. Neurosci. 6, 163 (2003); Lee, D. Endocrinol. 146, 231 (2005); Tatemoto, K. et al. Regul. Pept. 99, 87 (2001); Zou, M. et al. FEBS Lett. 473, 15 (2000); Wang, G. et al. Endocrinol. 145, 1342 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Pro - Arg - Leu - Ser - His - Lys - Gly - Pro - Met - Pro - Phe - OH