The octapeptide angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.
Ref: Cobb, C. et al. Gen. Comp. Endocrinol. 127, 8 (2002); Lundequist, A. et al. J. Biol. Chem. 279, 32339 (2004); Kinoshita, A. et al. J. Biol. Chem. 266, 19192 (1991); Spyroulias, G. et al. Eur. J. Biochem. 270, 2163 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Asp - Arg - Val - Tyr - Ile - His - Pro - Phe - OH