Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Amyloid Peptides  >  Beta-Amyloid (1-28) and Related Peptides  >>  Beta-Amyloid (12-28), Human

Product Name Beta - Amyloid (12 - 28), Human
VHHQKLVFFAEDVGSNK
Size 1 mg
Catalog # 24230
US$ $137
Purity % Peak Area By HPLC ≥ 95%
Description

Aß (12–28) residues are the binding site for apolipoprotein E (apoE) on Aß. This sequence encompasses a hydrophobic domain (residues 14–21) and a ß-turn (residues 22–28) which place two hydrophobic domains of Aß 14 to 21 and 29 to 40/42 opposite each other, allowing for the assembly of Aß peptides into fibrils. The secondary structure of Aß (12- 28), a neutral peptide, is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of Aß is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of Aß pathology in Alzheimer’s disease (AD). Aß (11-28) and five other fragments enhanced aggregation of full length Aß (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length Aß.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Sadowski, M. et al. Am. J. Pathol. 165, 937 (2004); Liu, R. et al. J. Neurosci. Res. 75, 162 (2004).
Molecular Weight 1955.2
Sequence
(One-Letter Code)
VHHQKLVFFAEDVGSNK
Sequence
(Three-Letter Code)
H - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - OH
Product Citations Libeu, CP. et al. (2011). Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimer's Dis 25, 547.
Wang, HY. et al. (2009). Dissociating β-amyloid from α7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes α7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. J Neurosci 29, 10961.
Solorzano-Vargas, RS. et al. (2008). Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42. Mol Immunol 45, 881.
     
  < Back