Catalog Peptides

MMP Peptide Substrates

Matrix metalloproteinases family

Matrix metalloproteinases (MMPs) are a family of highly homologous protein-degrading zinc dependent endopeptidases.

This family currently includes more than 25 members that can be divided into collagenases (MMP-1, 8, 13, 18), gelatinases (MMP-2 and 9), stromelysins (MMP-3, 10, 19), matrilysins (MMP-7, 11,  26), and the membrane-type MMPs (MMP-14 to 17, 24, 25).

Role of MMPs

MMPs are important in many normal biological processes including embryonic development, angiogenesis, and wound healing, as well as in pathological processes such as inflammation, cancer, and tissue destruction.

MMPs collectively cleave most, if not all, of the constituents of the extracellular matrix (ECM) and are involved in the breakdown and remodeling of many tissues and organs. Each MMP has preferred substrates, but a same substrate can usually be cleaved by more than one MMP.

Ref: Birkedal-Hansen, H. et al. Crit. Rev. Oral Biol. Med. 4, 197 (1993);  Lenhart, J. et al. Endocrinol. 142, 3941 (2001);  Gabison, EE. et al. Am. J. Pathol. 166, 209 (2005); Isaksen, B. and MK. Fagerhol, J. Clin. Pathol. Mol. Pathol. 54, 289 (2001).

We support advances in MMP researches by providing a unique collection of MMP substrates. Besides classical colorimetric substrates, proprietary dye/quencher FRET pairs allow us to propose high-quality fluorescent peptides.

Name Sequence

390 MMP Substrate

490 MMP Substrate

520 MMP Substrate

580 MMP Substrate

  Mca /
Edans /
5-FAM /
QXL® 520
QXL® 570

325/393 nm

340/490 nm

494/521 nm

547/574 nm

Substrate 1 dye-PLGL-Dap(quencher)-AR-NH2



Substrate 2 dye-PLGL-Dap(quencher)-AR


Substrate 3 quencher-PLGC(Me)HAr-K(dye)-NH2


Substrate 4 quencher-PLGLWArK(dye)-NH2


Substrate 5 dye-PLGLEEA-Dap(quencher)-NH2


Substrate 6 quencher-PLGMWSRK(dye)-NH2


Substrate 7 quencher-PYAYWMRK(dye)-NH2


Substrate 8 quencher-KPLA-Nva-Dap(dye)-AR-NH2


Substrate 9 quencher-RPLALWRK(dye)-NH2


Substrate 10 quencher-RPLALWRS-dye


Substrate 11 dye-P-Cha-G-Nva-HA-Dap(quencher)-NH2



Substrate 12 dye-RPKPYA-Nva-WMK(quencher)-NH2


Substrate 13 dye-RPKPVE-Nva-WRK(quencher)-NH2



Substrate 14 quencher-(γ-Abu)-P-Cha-Abu-Smc-HA-Dab(dye)-AK-NH2


Substrate 15 quencher-(γ-Abu)-PQGL-Dab(dye)-AK-NH2


Substrate 16 quencher-(γ-Abu)-PQGL-E(dye)AK-NH2


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