ClearPointTM β-Amyloid Peptides - NEW


The world’s largest source of b-Amyloid peptides and related products, AnaSpec is pleased to release our newest collection of ClearPoint™ b-Amyloid peptides.

ClearPoint™ peptides are AnaSpec’s trademark collection of heavy or stable isotope labeled peptides and amino acids. These peptides can be used for the quantitative analyses of b-Amyloid peptides in biological fluids using mass spectrometry (MS). The inclusion of internal heavy isotope labeled peptide standards makes mass spectrometry an absolute quantitation (AQUA) method for the peptide of interest.1

b-Amyloid (1-40) and (1-42) peptides have been used as biomarkers of Alzheimer's disease (AD). Historically, ELISA assays have been used in the quantitation of these peptides. However, technical challenges such as the tendency of b-Amyloid (1-40) and (1-42) peptides to self-aggregate, undergo post-translational modifications or bind to other proteins result in inaccuracies in quantitation when using ELISA.2 Oe, et al. reported the use of [15N]-labeled b-Amyloid peptides as internal standards using immunoaffinity purified CSF.2

Cat#

Mass increase

Description

1-letter

ClearPoint™ b-Amyloid (1-40), U-13C, 15N-labeled at Arg & Lys

63737

+26

All the Arginine and Lysines have universally labeled 13C and 15N.

DAEF-R*-HDSGYEVHHQ-K*-LVFFAEDVGSN-K*-GAIIGLMVGGVV

[R*=R(U-13C6, U-15N4) &

K*=K(U-13C6, U-15N2)]

ClearPoint™ b-Amyloid (1-42), U-13C, 15N-labeled at Arg & Lys

63738

+26

All the Arginine and Lysines have universally labeled 13C and 15N.

DAEF-R*-HDSGYEVHHQ-K*-LVFFAEDVGSN-K*-GAIIGLMVGGVVIA

[R*=R(U-13C6, U-15N4) &

K*=K(U-13C6, U-15N2)]

ClearPoint ™ b-Amyloid (4-42), U-13C, 15N-labeled at Arg & Lys

63739

+26

All the Arginine and Lysines have universally labeled 13C and 15N.

F-R*-HDSGYEVHHQ-K*-LVFFAEDVGSN-K*-GAIIGLMVGGVVIA

[R*=R(U-13C6, U-15N4) &

K*=K(U-13C6, U-15N2)]

ClearPoint™ b-Amyloid (1-40), U-13C-labeled at Leu17

63740

+6

Leu at position 17 has universally labeled 13C.

DAEFRHDSGYEVHHQK-L*-VFFAEDVGSNKGAIIGLMVGGVV

[L*=L(U-13C6)]

ClearPoint™ b-Amyloid (4-42), U-13C, 15N -labeled at Val12

63741

+6

Val at position 12 has universally labeled 13C and 15N.

FRHDSGYE-V*-HHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

V*=V(U-13C5, U-15N)

ClearPoint™ b-Amyloid (8-42), U-13C, 15N -labeled at Val12

63742

+6

Val at position 12 has universally labeled 13C and 15N.

SGYE-V*-HHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

V*=V(U-13C5, U-15N)

Samples of other newly released b-Amyloid GO™ Peptides:

[Cys26] - beta - Amyloid (1 - 40), S26C beta - Amyloid (1 - 40) NEW

1 mg

63671-1

[Cys26] - beta - Amyloid (1 - 42), S26C beta - Amyloid (1 - 42) NEW

0.5 mg

63672-05

[Cys40] - beta - hairpin (BHA), Protein G B1 Domain (41 - 56) NEW

1 mg

62533

[Cys7] - Beta - Amyloid (1 - 40) NEW

1 mg

62815-1

[Cys7] - Beta - Amyloid (1 - 40) NEW

0.5 mg

62815-05

[Gln22] - beta - Amyloid (15 - 23) NEW

1 mg

62892

[Gln22] - beta - Amyloid (1 - 40), Dutch Mutation

0.5 mg

61261

[Gly21] - beta - Amyloid (1 - 40), A21G, Flemish mutation NEW

0.5 mg

62150

[Gly22] - beta - Amyloid (1 - 40), Arctic Mutation

0.5 mg

61262

[Gly22] beta - Amyloid (1 - 42), Arctic Mutation NEW

0.5 mg

61967-05

[Lys22] Beta - Amyloid (1 - 42), Italian Mutation NEW

0.5 mg

62148

[Gly30, Cys31] beta - Amyloid (13 – 31)

1 mg

61800

[Gly35, Asp37] - Beta - Amyloid (1 - 42) NEW

0.1 mg

62832-01

[Gly35, Asp37] - Beta - Amyloid (1 - 42) NEW

0.5 mg

62832-05

[Ile34] Beta - Amyloid (25 – 34)

1 mg

61077-1

[Ile34] Beta - Amyloid (25 – 34)

5 mg

61077-5

[Leu35] - beta - Amyloid (1 - 42) NEW

0.5 mg

62143

[Leu35] - Met - beta - Amyloid (1 – 42)

0.1 mg

61957-01

World’s largest collection of b-Amyloid and Related Peptides

Click here to request the new Alzheimer’s Research Brochure

b-Amyloid on sepharose available. Send email to service@anaspec.com for more information.

Related Products:

Labeled Amyloid Peptides

SensoLyte™ 520 Beta-Secretase Assay Kit

SensoLyte™ 520 Alpha-Secretase Assay Kit

SensoLyte™ Cathepsin Assay Kits

Anti-Tau Antibodies – phospho and non-phosphorylated

DHL™ fluorescent b-Amyloid (1-40) & (1-42) Sampler Kits

Amyloid Vital Dyes

References

1. Harding, S. (ed.) 2007. Biotechnology & Genetic Engineering Reviews. Nottingham Univ. Press, Nottingham.
2. Oe, T. et al. Rapid Comm. Mass Spec. 20, 3723 (2006).