Peptides

Iberiotoxin (IbTX) - 0.1 mg

$172.00
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  • Cat.Number : AS-60763
  • Availability :
    In production

Quantity

A 37-amino acid peptide from the scorpion, Buthus tamulus, having 68% homology with charybdotoxin. It is a selective inhibitor of the highly conductance calcium-activated (maxi-K) potassium channels.

Specifications

Chemistry
Sequence one letter code
  • Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ(Disulfide bridge: C7-C28,C13-C33,C17-C35)
Sequence three letter code
  • Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bridge: C7-C28,C13-C33,C17-C35)
CAS registry number
  • 129203-60-7
Molecular Formula
  • C179H274N50O55S7
Molecular Mass/ Weight
  • 4231.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Scorpion

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Citations

Genetic basis of the impaired renal myogenic response in FHH rats.

Am J Physiol Renal Physiol . 2012 Dec 05 ; 304(5) F565 | DOI : 10.​1152/​ajprenal.​00404.​2012.

  • M. Burke

Activation of endothelial BKCa channels causes pulmonary vasodilation.

Vas Pharmacol . 2010 May 12 ; 53(3-4) 122 | DOI : 10.1016/j.vph.2010.05.00.

  • A. Vang

References

Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel

Biophys J . 1992 Aug 01 ; 63(2) 583 | DOI : https://doi.org/10.1016/S0006-3495(92)81630-2

  • S. Candia
  • et al